BOTOX® Cosmetic
(onabotulinumtoxinA) Important Information
Indication
BOTOX® Cosmetic is a prescription medicine that is injected into muscles and used to
improve the look of moderate to severe frown lines between the eyebrows
(glabellar lines) in people 18 to 65 years of age for a short period of
time (temporary).
IMPORTANT SAFETY
INFORMATION
BOTOX® Cosmetic
may cause serious side effects that can be life threatening. Call your doctor
or get medical help right away if you have any of these problems any time
(hours to weeks) after injection of BOTOX® Cosmetic:
-
Problems swallowing, speaking,
or breathing, due to weakening of associated muscles, can be severe and result in loss of life. You are at the highest risk
if these problems are pre-existing before injection. Swallowing problems may last for several months.
-
Spread of toxin effects. The effect of botulinum toxin may affect areas away
from the injection site and cause serious symptoms including: loss of strength
and all-over muscle weakness, double vision, blurred vision and drooping
eyelids, hoarseness or change or loss of voice (dysphonia), trouble saying
words clearly (dysarthria), loss of bladder control, trouble breathing, trouble
swallowing.
There has not been a confirmed serious case of spread of toxin effect when BOTOX® Cosmetic has been
used at the recommended dose to treat frown lines.
The dose of BOTOX®
Cosmetic is not the same as, or comparable to, any another botulinum toxin
product.
Serious and or immediate allergic reactions have been reported. These reactions include itchy rash, swelling, and shortness of
breath. Tell your doctor or get medical help right away if you experience
any such symptoms, further injection of BOTOX® Cosmetic should
be discontinued.
Do not take BOTOX®
Cosmetic if you: are allergic to any
of the ingredients in BOTOX® Cosmetic (see Medication Guide for
ingredients); had an allergic reaction to any other botulinum toxin product
such as Myobloc® or Dysport ®; have a skin
infection at the planned injection site.
Tell your doctor about all your muscle or nerve conditions such as
amyotrophic lateral sclerosis [ALS or LouGehrig's disease], myasthenia
gravis or Lambert-Eatonsyndrome as you may be at increased risk of
serious side effects including severe dysphagia (difficulty swallowing) and
respiratory compromise (difficulty breathing) from typical doses of BOTOX®
Cosmetic.
Tell your doctor about all your medical conditions, including if you have: plans to have surgery; had surgery on your face;
weakness of forehead muscles, such as trouble raising your eyebrows; drooping
eyelids; any other abnormal facial change; are pregnant or plan to become
pregnant (It is not known if BOTOX® Cosmetic can harm your unborn
baby); are breast-feeding or plan to breastfeed (It is not known if BOTOX®
Cosmetic passes into breast milk).
Tell your doctor about all
the medicines you take, including
prescription and nonprescription medicines, vitamins and herbal
products.
BOTOX® Cosmetic may cause loss of strength or general
muscle weakness, or vision problems. If this happens, do not drive a car,
operate machinery, or do other dangerous activities.
Other side effects of BOTOX® Cosmetic include: dry mouth,
discomfort or pain at the injection site, tiredness, headache, neck
pain, and eye problems: double vision, blurred vision, decreased
eyesight, drooping eyelids, swelling of your eyelids, and dry eyes. For more information refer to
the Medication Guide or talk with your doctor.
You are encouraged to report negative side effects of prescription drugs to the
FDA. Visit www.fda.gov/medwatch, or call
1-800-FDA-1088.
Please see BOTOX®
Cosmetic full Product Information, including
Medication Guide.
